Explore the intricate world of cyberdefense in this 1-hour 24-minute lecture by Stephanie Forrest at the Santa Fe Institute. Delve into the parallels between biological defense systems and cybersecurity, examining how concepts from immunology are being adapted to address digital threats. Investigate the evolution of computer attacks, malware, and new vulnerabilities while considering the complex interplay between cyberspace, economics, social interactions, and politics. Learn about various attack types, including man-in-the-middle and buffer overflow, and discover innovative defense strategies such as address space randomization and network immunology. Gain insights into the challenges of zero-day attacks and the potential for building a digital immune system to combat emerging threats in our increasingly interconnected world.