Explore the science behind global pandemics in this 1-hour 12-minute public lecture by Professor Lauren Meyers. Delve into the ongoing threat of influenza and discover how mathematical modeling combined with high-performance computing is revolutionizing disease surveillance, forecasting, and control. Gain insights into the big picture of pandemics, understand flu curves and networks, and learn about data sources and decision support tools. Examine the role of supercomputers in predicting influenza seasons and respiratory disease activity. Investigate surge planning strategies and explore the big questions surrounding pandemic science. Recorded on December 4, 2013, this comprehensive talk offers a deep dive into the cutting-edge approaches used to combat and understand global health crises.