Explore the transformative impact of personal genomics in this lecture from the Santa Fe Institute's Annual Science Board Symposium. Delve into the mission of 23andMe, examining health-related reports, drug response stories, and customer experiences. Discover how personal genomics is revolutionizing healthcare, ancestry research, and identity exploration. Learn about the clinical utility of genetic information and its role in pharmacogenetics. Investigate ongoing research in areas such as Parkinson's disease and nearsightedness. Gain insights into human prehistory and the future of genomics. Examine the growth of the field, research opportunities, and privacy considerations in this comprehensive overview of personal genomics and its potential to change lives and transform scientific research.