Explore the complexities of measuring quality and value in healthcare through this insightful 47-minute lecture from the Santa Fe Institute's Annual Science Board Symposium. Delve into five key topics, including cardiovascular disease, healthcare delivery systems, and potential pitfalls in the industry. Examine the challenges of defining value in healthcare, the role of Accountable Care Organizations (ACOs), and the issue of waste in the system. Learn about federal initiatives like PCAST and Health Datapalooza, and understand the importance of big data in improving healthcare outcomes. Discover the significance of the National Quality Forum and population health measures. Engage with thought-provoking questions on systems engineering approaches, observational studies, and international healthcare comparisons. Gain valuable insights into the potential contributions of the Santa Fe Institute in advancing healthcare science and innovation.