Histones are molecular spools that pack DNA into the cell
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Amazing thing: spools can be programmed in the womb and during life
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Histones contain tails that can be programmed (on/off)
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Epigenetics: complex layer of circuitry that programs the DNA • Each spool is a chemical switch
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DNA sequencing technology has fueled epigenetics
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The killer app: stem cells
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Waddington's epigenetic landscape
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The ski trail metaphor
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Stress response and nature vs. nurture
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Biochemistry of Stress Baseball
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Stress response: cortisol control
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Thermostat controls temperature
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Stress thermostat out of whack!
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Landmark epigenetic study: Mother rats licking and grooming their pups and the effect on pups' DNA
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Environment of mother mouse affects great-grandchildren (Skinner, PLoS One 2012)
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Related epigenetic effects in humans
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Back to smart phone metaphor
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Back to ski trail metaphor
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Epigenetics of Normal Cells
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Other epigenetic programming errors
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Epigenetic cancer drugs
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How do programmers find the right places on the DNA, at the right times?
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RNA is DNA's molecular cousin
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The cutting edge of epigenetics • Linc-RNAs guide programmers to DNA in
Description:
Explore the fascinating world of epigenetics in this 50-minute lecture by Dr. Karissa Sanbonmatsu from the Santa Fe Institute. Delve into the complex interplay between DNA, environment, and human behavior, uncovering how epigenetic mechanisms influence traits beyond simple nature vs. nurture explanations. Learn about the role of histone proteins in DNA packaging and programming, and discover how stress responses can alter genetic expression across generations. Examine groundbreaking research on maternal behavior in rats and its lasting impact on offspring DNA. Investigate the potential applications of epigenetics in understanding and treating conditions like autism, addiction, depression, and Alzheimer's disease. Gain insights into the cutting-edge field of long non-coding RNAs and their significance in guiding epigenetic programmers to specific DNA locations. Through engaging metaphors and real-world examples, grasp the fundamentals of this revolutionary science that may hold the key to comprehending complex human experiences, including love.
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