Explore key insights in rheumatology through this 41-minute physician grand rounds presentation. Delve into topics such as ANA testing, catastrophic antiphospholipid syndrome, scleroderma renal crisis, and the cardiovascular risks associated with rheumatic diseases. Learn about the impact of various treatments, including TNF inhibitors, methotrexate, NSAIDs, and steroids, on cardiovascular events in rheumatoid arthritis. Gain valuable knowledge on reproductive health considerations for patients with rheumatic conditions, including contraception choices and ineffective methods. Examine steroid use in giant cell arteritis and steroid-sparing approaches in granulomatosis with polyangiitis. Conclude with essential take-home points to enhance your understanding and clinical practice in rheumatology.