Explore the complexities of fitting high-dimensional data and model selection in this 38-minute lecture by Bruce Walsh, part of the "Theoretical and Empirical Approaches to Understand Polygenic Adaptation" program at the International Centre for Theoretical Sciences. Delve into the challenges of understanding phenotypic variation in terms of underlying genetic variation, a central problem in biological evolution. Learn about recent insights into the genetic architecture of polygenic traits, which influence a wide range of phenotypes from crop yield to human height and complex diseases. Examine the integration of two contrasting views on adaptive dynamics: adaptation through large changes at few genetic loci versus infinitesimal changes at numerous loci. Gain valuable knowledge on quantitative descriptions of various adaptation scenarios and their relation to empirical data. This lecture is part of a comprehensive program featuring pedagogical lectures, research seminars, and dedicated tutorial and discussion sessions, aimed at fostering an inclusive and diverse scientific environment. Read more