Explore the fascinating world of DNA visualization in living cells through fluorescence techniques in this 53-minute lecture by Dr. Elizabeth Hinde. Discover how physics enables real-time observation of DNA network spatial reorganization, potentially serving as an epigenetic control layer for gene expression. Learn about the challenges of optical microscopy in observing DNA organization due to diffraction limits, and understand the breakthrough collaborations between physics, chemistry, and biology that led to super-resolution imaging. Delve into the intricacies of genome architecture, live cell nanoscale genome dynamics, and how nuclear architecture facilitates DNA repair factor navigation. This lecture, part of the University of Melbourne's Science Festival, offers insights into the complex relationship between genome size, organism complexity, and gene count, while highlighting the potential functions of non-coding DNA.