Explore the fundamental concepts of truth and scientific methodology in this 43-minute lecture by David Gross at the International Centre for Theoretical Sciences. Delve into topics such as the SACHDEV-YE KITAEV Model, the nature of scientific truth, and the strengths and limitations of science. Examine how the scientific method thrives in open societies, the role of reductionism, and the challenges facing modern science. Gain insights into why science will ultimately triumph and participate in a thought-provoking Q&A session. This talk, part of the "ICTS at Ten" event, offers a broad perspective on frontier questions in theoretical sciences, including astrophysics, string theory, mathematics, and physical biology.