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Introduction to NMR spectroscopy
2
The alignment of nuclear spins in presence of magnetic field
3
Introduction to rotating frame
4
Free induction decay and Fourier transformation of FID
5
NMR Hardware
6
The concept of chemical shift
7
Factors that affect chemical shifts
8
Chemical shift referencing
9
J- coupling
10
Recap of basics
11
Introduction to general one dimensional NMR experiment
12
Practical aspects of recording a 1D NMR experiment I
13
Practical aspects of recording a 1D NMR experiment II
14
Lec14 Practical aspects of recording a 1D NMR experiment III
15
NMR Data processing
16
Basic aspects of 1D proton NMR analysis
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Analysis of an example 1D proton spectrum
18
Analysis of 1D 1H NMR spectra of molecules I
19
Analysis of 1D 1H NMR spectra of molecules II
20
1D 13C NMR
21
Why do we need 2D NMR
22
A qualitative explanation of how 2D NMR experiment works
23
Principles of 2D COSY and Total correlation spectroscopy (2D TOCSY)
24
2D NOE-spectroscopy
25
2D NOESY and 2D ROESY
26
What is heteronuclear correlation NMR spectroscopy
27
Sensitivity enhancement of heternuclei via polarization transfer
28
Heteronucler multiple(2D HMQC) and single quantum NMR spectroscopy (2D HSQC)
29
Practical aspects of recording and processing 2D HMQC or HSQC
30
HMBC and its utility
31
2D HSQC TOCSY and its analysis with examples
32
Structure determination of molecules by NMR
33
Structure determination of peptides I
34
Structure determination of peptides II
35
Structure determination of peptides III
36
Chemical exchange
37
Hydrogen or deuterium exchange
38
Diffusion ordered spectroscopy DOSY I
39
DOSY II
40
STD NMR for drug target interactions
Description:
The objective of the course is to teach the basic aspects of nuclear magnetic resonance (NMR) spectroscopy, which is an important analytical tool in chemical and pharmaceutical industry for the structural characterization of molecules. The topics to be covered will include one-dimensional NMR, Chemical shifts, J-coupling, Interpretation of 1D NMR spectrum, Basics of 2D NMR, Different 2D NMR experiments and their application/interpretation, Application of 2D NMR for assignment of molecules and peptides.

Principles and Applications of NMR Spectroscopy

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Introduction to NMR spectroscopy