Explore key concepts in biomolecular engineering through this 53-minute lecture from Yale University's Frontiers of Biomedical Engineering course. Delve into pharmacokinetics and pharmacodynamics, examining dose-response relationships and various drug administration routes. Learn about intravenous, oral, and sublingual delivery methods, their effects on drug distribution, and bioavailability. Understand the impact of first-pass liver metabolism on drug degradation. Discover how to model the body as a well-stirred vessel using first-order rate equations to calculate drug concentration over time. Gain insights into drug half-life calculations and explore topics such as drug delivery introduction, dosage-response relationships, injection methods, oral drug delivery, and drug bioavailability.