Explore the intersection of data science and clinical decision-making in this 38-minute conference talk. Delve into the opportunities and challenges presented by electronic health records, and discover strategies for making clinical data more usable and effective. Learn about applying natural language processing to transform clinical documentation into structured data for surveillance and prediction applications. Gain insights into patient-derived data, informatics in medicine, evidence-based medicine, and systematic review of evidence. Examine timelines of clinical events, risk prediction for patients with atrial fibrillation, and the differences between structured and unstructured data. Investigate automated information extraction techniques, including family history relation extraction and neural methods. Understand DRG prediction methods, medical data characteristics, and the importance of data reusability in supporting clinical decision-making.