Explore the frontiers of semiconductor technology through predictive atomistic calculations in this Distinguished Lecture by Prof. Emmanouil Kioupakis from the University of Michigan. Delve into the fundamental limitations and discover new materials in semiconductor research. Examine quantum processes in semiconductor devices, focusing on phonon-mediated processes and their impact on optical absorption. Investigate challenges in nitride LEDs, ultra-wide-band-gap semiconductors, and the limitations of alloy disorder in AlGaN mobility. Learn about defect calculation methods, the Baliga Figure of Merit, and recent advancements in epitaxial thin films. Gain insights into co-doping acceptors with hydrogen and understand the timeless and timely problems in semiconductor technology for electrons and energy applications.