Explore a comprehensive grand rounds lecture on schizoaffective disorders and precision medicine from Johns Hopkins Psychiatry and Behavioral Sciences. Delve into the challenges of heterogeneity in schizophrenia, examining approaches based on clinical phenotype and treatment response. Learn about the Johns Hopkins Schizoaffective Disorders Precision Medicine Center of Excellence (PMCOE) and its organization, guiding hypotheses, and levels of analysis. Discover the clinical components, assessment protocols, and research questions addressed by the PMCOE. Investigate cutting-edge circuitry projects, including thalamo-cortical connectivity abnormalities detected with 7T MRI and electrophysiological studies. Examine cell pathology research, focusing on protein aggregation and extracellular vesicles as potential pathogenic markers. Gain insights into genetic studies involving CUL1 and ANK3, and their implications for mood disorders and schizophrenia. Presented by Russell Margolis, M.D., this lecture offers a deep dive into the latest advancements in understanding and treating schizoaffective disorders through precision medicine approaches. Read more