Explore a comprehensive grand rounds lecture on the intricate relationship between Polycystic Ovary Syndrome (PCOS), mood and anxiety symptoms, and neuroactive steroids. Delve into the diagnosis, comorbidities, and psychiatric disorders associated with PCOS, as presented by Dr. Lindsay Standeven from Johns Hopkins Psychiatry and Behavioral Sciences. Gain insights into the biological basis of PCOS, including the role of neurosteroids in psychiatric illnesses, particularly depression. Examine animal models and clinical research findings, including study design and data on demographics, quality of life, and patient symptoms. Learn about premenstrual tension, depression, and anxiety symptoms in PCOS patients. Discover future directions for research and treatment in this complex field. Conclude with a Q&A session to further expand your understanding of this important topic in reproductive and mental health.