Explore cardiac amyloidosis, an underdiagnosed condition, in this comprehensive Grand Rounds presentation by Dr. Kevin Michael Alexander, Assistant Professor of Cardiovascular Medicine at Stanford. Delve into clinical subtypes, pathophysiology, mechanisms, and molecular studies of this disease. Discover the importance of early diagnosis, imaging techniques, biopsy procedures, and screening algorithms. Learn about current treatments, including FDA-approved medications and ongoing clinical trials. Gain insights into challenges in treatment access, research opportunities, and the significance of amyloidosis in diverse populations. Understand the role of machine learning and AI in diagnosis, environmental risk factors, and the potential of gene editing. Address common questions about beta blockers, ACE inhibitors, biomarkers, genetic testing, and recommendations for primary care doctors in managing this condition.