Explore the critical yet often overlooked genetic condition of familial hypercholesterolemia (FH) in this informative 48-minute lecture by Dr. Joshua W. Knowles from Stanford University. Learn about the genetic predisposition to extremely high LDL cholesterol levels, its potential for causing premature fatal heart attacks, and the effective statin-based therapies available. Discover why 90% of FH patients are unaware of their condition and the challenges in physician awareness and patient screening. Delve into the familial aspects of FH, new research for early diagnosis, and the importance of early intervention. Gain insights into FH treatments, including medications and lifestyle modifications, as well as the role of genetic testing and initiatives like the FH Foundation in improving diagnosis and care. Understand the significance of cholesterol levels, physical exam findings, and the liver's role in FH. Explore cutting-edge topics such as PCSK9 inhibitors, machine learning applications, and ongoing research efforts to combat this potentially life-threatening condition. Read more