Explore the clinical uses and adverse effects of aminoglycosides in this comprehensive 32-minute video lecture. Learn about the major toxicities, including ototoxicity, nephrotoxicity, and paralysis, as well as precautions for pregnant women. Discover the advantages of topical administration and high-dose extended interval regimens. Understand the synergistic use of aminoglycosides and their applications in various infections, such as neonatal meningitis, sepsis, pulmonary infections, cystic fibrosis, and infective endocarditis. Examine the use of aminoglycosides in infections above and below the diaphragm, including bone and joint conditions and skin and soft tissue infections. Gain insights into the specific use of neomycin in hepatic encephalopathy and learn when aminoglycosides are used as monotherapy.