Explore a comprehensive explanation of the HLA-B27 test and its significance in diagnosing Ankylosing Spondylitis (AS) in this informative 11-minute video by a rheumatologist. Learn about the genetic marker's role in immune system function, its association with AS and other spondyloarthropathies, and why it's not the sole determinant for diagnosis. Discover when HLA-B27 testing may be warranted, how to interpret test results, and the importance of considering other factors such as symptoms, imaging, and additional tests. Gain insights into the broader diagnostic process for AS, including the use of MRI and inflammatory markers. Use the provided time stamps to navigate key topics, including an introduction to HLA-B27, genetic risk for AS, result interpretation, the spondyloarthritis umbrella, and conversation starters for discussing your condition with your doctor.