Explore a thought-provoking 12-minute conference talk that challenges conventional approaches to antimicrobial resistance. Delve into the crucial role of beneficial bacteria in human health and learn how protecting the microbiome can help combat this global health threat. Discover why a paradigm shift in our relationship with microbes is necessary, and examine the unintended consequences of widespread antimicrobial and disinfectant use. Gain insights into innovative strategies, including targeted treatments and rapid diagnostics, that can help preserve beneficial microbes while effectively addressing harmful pathogens. Presented by Dr. Amy Mathers at ASM Microbe 2024, this talk covers topics such as the microbial nature of antibiotic resistance, the importance of microbes in human and animal health, the impact of disinfectants on microbial communities, and the potential link between microbiome disruption and conditions like obesity.