Explore key concepts in medical imaging analysis through this comprehensive 29-minute video lecture. Delve into the fundamentals of noise, bias, and contrast in imaging, and understand their significance in image quality assessment. Learn about crucial metrics such as Mean Squared Error (MSE), Contrast-to-Noise Ratio (CNR), and Contrast Recovery Coefficient (CRC). Discover how these metrics interrelate and how they are affected by various image reconstruction and generation methods. Gain insights into noise-bias trade-off curves, the Rose criterion, and the importance of task-based analyses in medical imaging. By the end of this lecture, acquire a solid understanding of the three generations of image analysis and their implications for modern medical imaging techniques.