Explore a comprehensive grand rounds lecture on modeling anorexia nervosa presented by Tim Moran, Ph.D. at Johns Hopkins Psychiatry and Behavioral Sciences. Delve into the complex interplay between physical activity, ingestion, and the development of anorexia nervosa through the Activity Based Anorexia (ABA) model. Examine how ABA affects cognitive function, taste perception, and stress responses in rodents. Investigate the role of prenatal stress in coping styles and the impact of hypothalamic neurons on ABA susceptibility. Gain insights into protective factors against ABA and the importance of food anticipatory activity. Learn about various experimental techniques used in eating disorder research, including wheel running, novel object recognition, conditioned taste avoidance, and defensive burying tests. Understand the neurobiological changes associated with ABA, such as increased oxidative stress in prefrontal cortex neurons. This in-depth presentation offers valuable knowledge for researchers, clinicians, and students interested in the neurobiology and etiology of eating disorders. Read more