Explore a keynote address from AppSecEU 2016 in Rome, delivered by Charlie Miller, focusing on the impact of bugs on software security. Delve into various methods of vulnerability analysis, including static and dynamic approaches, and their respective weaknesses. Learn about factors influencing application selection for security testing, distribution of applications, and the challenges of exploitation. Gain insights from real-world case studies, including instrumenting WebKit, fuzzing PCRE, and discovering an iOS code signing bug. Understand the importance of thorough testing and the potential consequences of overlooked vulnerabilities in software development and security.