Explore the complexities of building trust in science during times of uncertainty in this thought-provoking panel discussion featuring prominent experts in infectious diseases, science communication, and information warfare. Delve into the challenges of communicating evolving scientific knowledge, combating misinformation, and fostering trust in marginalized communities. Examine the role of scientific uncertainty, the process of building scientific consensus, and the impact of state-sponsored disinformation during global pandemics. Gain insights on selecting trusted messengers, understanding the democratization of science, and navigating the interconnectedness of global health decisions. Reflect on the implications of trust-based decisions for future generations and prepare for emerging infectious disease threats by learning from experts in the field.