Explore a comprehensive lecture on building a scalable clinical genomics program for cancer care, risk assessment, and detection. Delve into advanced NGS-based DNA testing techniques, including tumor tissue profiling, clinical interpretation of sequence variants, and automated monitoring for precision oncology. Learn about data sharing paradigms, clinical germline assessment, and the implications of tumor/normal sequencing for cancer risk inference. Examine the prevalence of clonal hematopoiesis and its clinical significance. Investigate the limitations of tissue-based DNA sequencing and the potential of plasma cell-free DNA profiling. Discover cutting-edge approaches to rare variant detection, including ultra-deep sequencing and error suppression techniques. Gain insights into polyclonal acquired resistance in cancer treatment and ongoing efforts to increase sensitivity in detecting circulating tumor DNA. Explore future prospects for clinical sequencing, including the incorporation of more genes, non-coding regions, and viral DNA analysis. Read more