Explore a theragnostic 3D ultrasound imaging system for high-resolution image-guided therapy in this Stanford Radiology PHIND Winter 2022 lecture. Delve into the principles of ultrasound imaging, ultrafast imaging paradigms, and challenges in clinical ultrasound. Learn about wider arrays, the 1024-channel system, and large aperture geometries including ring and 2D arrays. Discover optimization techniques for image-guided gene delivery, design geometry, and imaging performance. Examine 2D plane wave compounding, image formation processes, and the importance of elevation focusing. Investigate ex vivo assessment of microbubble sonication and strategies to optimize 1024 channels for small lesion detection. Gain insights into breast imaging applications and explore a wide range of potential clinical uses for this advanced imaging technology.