Explore the transition to COVID-19 endemicity and its implications in this insightful panel discussion featuring experts in mathematical biology, global health, and epidemiology. Delve into the complexities of defining endemicity, the potential for new variants, and the challenges of providing policy recommendations based on available data. Gain valuable insights on future public health measures, including booster shots and mask-wearing, as well as the lessons learned from two years of pandemic response. Examine the global perspective on managing SARS-CoV-2, the importance of sensitivity analysis in modeling, and the intricate interactions between government officials and scientists in shaping public health policies.