Discover how an innovative technique borrowed from the microelectronics industry revolutionizes biomimicry in drug development. Explore the Particle Replication in Non-wetting Templates (PRINT® Platform) and its applications in targeting diseased cells and bacteria while sparing healthy tissue. Learn about the role of physical properties in cell behavior, translational research vision, and the importance of particle shape in inhalation delivery. Delve into the design of Trojan Horse particles, the impact of mechano-biology on biodistribution, and the evolution of vaccines. Gain insights into PRINT therapeutics for respiratory diseases, pathogen invasion of cells, and the physical characteristics of pathogens. Examine plasma and tumor distribution profiles, and understand the progression from whole pathogen vaccines to modern influenza vaccines in this enlightening 20-minute TEDMED talk by Joseph DeSimone.