Explore groundbreaking research on genetic prediction of traits and diseases across diverse populations in this Radcliffe Institute talk. Delve into the innovative work of Alicia R. Martin, a research fellow at Massachusetts General Hospital and Broad Institute, as she discusses the analysis of genetic change, examining both historic and current adaptations. Learn about the interplay between genetics and the environment, liability thresholds, and polygenic risk in relation to heart disease. Discover the importance of diversity in human genetics studies and the impact of human evolutionary history on polygenic prediction. Gain insights into large-scale genetic studies, including the UK Biobank Study, and understand the progress towards parity in genetic prediction accuracy across populations. This presentation, part of the Next in Science series, offers a unique opportunity to engage with cutting-edge research in the field of evolution and genetics.