Explore the historical context of the reproducibility crisis in scientific research through this insightful lecture by Nicole C. Nelson, delivered at the Radcliffe Institute for Advanced Study. Delve into the phenomenon of scientists struggling to replicate supposedly stable findings and its implications for scientific fact. Examine survey data, historical perspectives on clinical research reform, evidence-based medicine, and publication bias. Investigate productivity declines, power dynamics in research, and internal laboratory processes. Gain valuable insights into the interpretive space of scientific inquiry and potential solutions to address the reproducibility challenge. Engage in a thought-provoking discussion that bridges scholarly and public understanding of scientific methodology and its evolving nature.