Explore a comprehensive lecture on optimizing antibiotic therapy for critically ill patients in intensive care settings. Delve into the importance of antimicrobial stewardship, practical day-to-day management of infections, and the challenges of applying pharmacokinetic and pharmacodynamic principles in critically ill patients. Learn about microbiology pitfalls, multi-disciplinary team approaches, and strategies for optimizing antibiotic use and non-use. Gain insights from Dr. Brendan Healy's 15 years of experience as a consultant in microbiology and infectious diseases, covering topics such as increasing bacterial resistance, repurposed antibiotics, appropriate clinical assessment, causes of antibiotic failure, sensitivity testing, and optimization of dosing for various antibiotic classes. Understand the complexities of managing ICU-related infections, interpreting chest x-rays, and addressing penicillin allergies to improve patient outcomes in critical care environments.