Explore modern epidemics in this Radcliffe Institute Science Symposium talk by Kevin M. Esvelt, leader of the Sculpting Evolution Group and assistant professor at MIT Media Lab. Delve into innovative approaches to combat disease transmission, including the "Mice Against Ticks" project and potential applications of CRISPR technology. Learn about community-guided research, the importance of humility in scientific endeavors, and the ethical considerations surrounding gene drive technologies. Examine case studies on malaria and schistosomiasis, and discuss the potential risks and benefits of local gene drives. Gain insights into laboratory safety, off-target effects, and the quorum effect in genetic interventions. The talk concludes with an audience Q&A session, providing further exploration of these cutting-edge topics in epidemiology and biotechnology.