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on
1
00:00:00 - Brief overview of previous lecture
2
00:01:50 - What is an agonist?
3
00:03:15 - What is the difference between agonist and antagonist?
4
00:04:56 - Different types of agonists
5
00:05:22 - Full agonist
6
00:06:20 - What is affinity?
7
00:08:24 - Efficacy of ligand intrinsic activity
8
00:10:30 - Partial Agonist
9
00:15:13 - Full agonist vs Partial agonist
10
00:16:20 - Partial agonists as antagonists
11
00:20:00 - Rationale of use of partial agonists as drugs
12
00:24:00 - Examples of full agonists, partial agonists, and opioid receptors
13
00:28:50 - Orthosteric agonist vs Allosteric agonist
14
00:35:54 - Positive Allosteric Modulator
15
00:40:37 - Inverse agonist with examples
16
00:49:57 - allosteric agonist example
17
00:51:53 - Positive Allosteric Modulator example
18
00:52:40 - How Benzodiazepines work
19
00:59:01 - Benzodiazepines vs Barbiturates
20
01:03:38 - Direct agonist and Indirect agonists
21
01:12:32 - Review of the lecture
Description:
Dive into a comprehensive 1-hour 19-minute lecture on receptors, agonists, and their types. Explore the differences between agonists and antagonists, understand various agonist types including full, partial, orthosteric, and allosteric. Learn about affinity, efficacy, and intrinsic activity of ligands. Discover the rationale behind using partial agonists as drugs and examine examples of full and partial agonists in opioid receptors. Investigate positive allosteric modulators, inverse agonists, and the mechanisms of benzodiazepines and barbiturates. Conclude with an overview of direct and indirect agonists, providing a thorough understanding of receptor pharmacology.

Receptor - Agonist and Its Types

Dr. Najeeb Lectures
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