Explore the complex world of gene regulation and expression in this 44-minute Radcliffe Institute Fellows' Presentation by Thomas Lenormand, CNRS research director and 2017-2018 Hrdy Fellow at Harvard University. Delve into microevolution, macroevolution, and evolutionary theory while examining major transitions in groups, energy, and genetic systems. Investigate the history of prokaryotes and eukaryotes, focusing on reproduction and transcription initiation. Analyze concepts such as trans and cis-regulation, dominance, genetic load, diploidy, and the selfish gene through various metaphors. Examine diploid expression, fitness relationships, and the evolution of regulatory regions. Gain insights into the coevolution of regulators, cis-cis interactions, and the role of regulation in modern synthesis, providing a comprehensive overview of this fascinating field of biology.