Explore a comprehensive World Shared Practices Forum lecture on leading towards zero harm in pediatric healthcare, delivered by Dr. Richard Brilli, Chief Medical Officer at Nationwide Children's Hospital. Gain insights into the development and implementation of prevention bundles for catheter-associated bloodstream infections in pediatric ICUs. Learn about the motivations behind this initiative, the lessons learned, and the significant impact on reducing infection rates. Discover the evolution of patient safety practices, including the creation of evidence-based protocols, the importance of quality improvement science, and the role of leadership in achieving high reliability in healthcare. Understand how this groundbreaking work has shaped current approaches to preventing hospital-acquired conditions and improving patient outcomes in pediatric critical care settings worldwide.