Explore the advantages and disadvantages of biomarker-based endotyping in critical care research through this 31-minute video lecture by Dr. Nadir Yehya. Delve into the impact of biomarkers on endotyping, subphenotyping, and enrichment for critical care trials, with a focus on sepsis and ARDS. Gain insights into existing literature in adult and pediatric sepsis and ARDS, and examine the strengths and weaknesses of using biomarkers in research. Learn about the challenges in studying sepsis and RDS, the limitations of biomarkers, and their future potential in critical care. Engage with audience questions to further enhance understanding of this complex topic.