Explore the evolution and current understanding of septic shock in this comprehensive lecture by Dr. Margaret Parker, a renowned expert in Pediatric Critical Care Medicine. Delve into the history of septic shock, ventricular dysfunction, and hemodynamic monitoring approaches in sepsis. Learn about seminal publications, uniform definitions, myocardial depressant factors, and goal-directed therapy. Examine the controversies surrounding fluid resuscitation, including insights from East African studies. Analyze the evidence for protocol-based management and discuss optimal monitoring techniques for septic shock patients. Gain valuable knowledge to enhance your clinical practice in treating critically ill children with sepsis.