Explore the intricacies of genomic science in this 42-minute lecture from the DNA Lecture Series at Harvard University's Radcliffe Institute for Advanced Study. Delve into the concept of "tiling the genome" and its potential impact on precision medicine with Alexander (Sasha) Wait Zaranek, chief scientist at Curoverse Inc. and director of informatics at the Harvard Personal Genome Project. Learn about the challenges and opportunities in organizing computational resources for genomic analysis, the importance of sharing and privacy in genomic data, and the role of open-source platforms like Arvados. Discover how clinical genetics and tools such as Principal Component Analysis are shaping our understanding of individual genomes. Gain insights into the future of personalized healthcare as Zaranek discusses the potential for doctors to utilize individual DNA information in medical practice.