Explore a comprehensive lecture on sepsis in critically ill children delivered by Dr. Adrienne Randolph, a renowned expert from Boston Children's Hospital and Harvard Medical School. Delve into the burden of sepsis, prevention strategies, and the latest consensus on sepsis definitions. Learn about fluid management in shock, antimicrobial therapy, and host considerations. Discover the importance of identifying the type and cause of shock, and gain insights into future research directions, including environmental factors and prevention of secondary sepsis. This 46-minute presentation, part of the OPENPediatrics platform, offers valuable knowledge for healthcare clinicians worldwide caring for critically ill children in various resource settings.