Explore advances in inflammatory bowel disease (IBD) management through this comprehensive grand rounds presentation by Dr. Edward Loftus, Jr. from Mayo Clinic's Gastroenterology/Hepatology department. Delve into the changing geographic distribution of IBD, main susceptibility genes for Crohn's disease, and microbial diversity. Learn about treatment strategies for ulcerative colitis and Crohn's disease, including the efficacy of various medications such as azathioprine, infliximab, and other biologic agents. Examine factors influencing disease progression, surgical outcomes, and the importance of monitoring drug levels and antibodies in TNF antagonist therapy. Gain insights into the latest research on predictors of severe disease, mucosal healing, and pharmacokinetics of IBD treatments.