Explore the latest insights on osteoporosis screening, diagnosis, and treatment in this comprehensive medical grand rounds presentation. Learn when to screen for osteoporosis, identify clinical risk factors, and understand the significance of low-impact fractures. Discover the causes of bone loss, evaluation methods for secondary osteoporosis, and how to assess fracture risk in osteopenic patients using FRAX. Examine available osteoporosis medications, their efficacy in fracture protection, and criteria for treatment failure. Delve into the topic of subtrochanteric fractures, their relationship with bisphosphonates, and the importance of bone turnover. Investigate the possibility of discontinuing bisphosphonate treatment, referencing the FLEX trial. Finally, analyze the effects of Denosumab on bone density and fracture risk, along with associated safety concerns.