Explore the emerging role of the circadian system in glucose homeostasis in this 47-minute physician grand rounds presentation from Mayo Clinic's Dr. Aleksey Matveyenko. Delve into the global prevalence of Type 2 diabetes, islet failure mechanisms, and the endocrine pancreas overview. Examine pancreatic beta cell failure in Type 2 diabetes and gain insights into circadian system fundamentals. Investigate circadian rhythms in B-cell function and their connection to T2DM development. Uncover the molecular basis of circadian rhythms in pancreatic islets and their control over insulin secretion and glucose metabolism. Learn about circadian disruption's impact on beta cell failure and the potential for chronomedicine. Understand the crucial role of circadian clocks in B-cell function and turnover in this comprehensive exploration of timing's significance in glucose regulation.