Explore the complexities of headache diagnosis and treatment in this comprehensive physician grand rounds lecture. Delve into multiple case studies, examining various headache types and their underlying causes. Learn about headache nosology, migraine pathophysiology, and genetics. Discover both abortive and preventative treatment options, including innovative electrical devices. Gain insights into essential history-taking and physical examination techniques for headache patients. Investigate the potential link between climate change and headaches, concluding with thought-provoking considerations on societal impacts.