Explore a cutting-edge approach to protecting genomic data from brute-force attacks in this IEEE conference talk. Dive into the innovative GenoGuard tool, which leverages honey encryption techniques to provide information-theoretic confidentiality guarantees for encrypted genetic information. Learn how this solution addresses the challenges of applying honey encryption to the non-uniform probability distributions characteristic of genomic sequences. Discover the tool's ability to generate plausible genome sequences for any decryption attempt, offering robust security against message-recovery attacks. Examine the performance evaluation, implementation details, and potential vulnerabilities to side-information attacks. Gain insights into the critical importance of securing genetic data in an era of advancing interpretative capabilities and growing database populations.