Explore an in-depth update on cryptococcal disease in HIV-infected patients presented by Graeme Meintjes from the University of Cape Town. Delve into the burden of cryptococcal meningitis in South Africa, examining laboratory-confirmed cases and case fatality rates. Learn about the CrAg Lateral Flow Assay and its implementation challenges. Analyze the ORCAS trial and WHO Guidelines from 2011. Investigate the COAT trial, which studied optimal ART timing in cryptococcal meningitis patients. Examine causes of death and the potential risks of early ART initiation. Gain insights into CSF findings and draw important conclusions about managing cryptococcal disease in HIV patients.