Explore the latest trends in illicit substances and their impact on emergency medicine in this informative conference talk from the 2021 ACOEP Scientific Assembly. Delve into the world of novel synthetic opioids, sedatives, stimulants, cannabinoids, and other emerging street drugs. Gain valuable insights on how to identify, treat, and manage patients affected by these substances. Learn about the objectives, epidemiology, and clinical presentations associated with various drug categories. Discover practical strategies for healthcare professionals to address the challenges posed by evolving drug trends. Enhance your knowledge through real-world case studies and a comprehensive summary of key takeaways, equipping you with essential information to provide optimal care in emergency situations involving up-and-coming street drugs.