Explore the critical role of bioengineering in vaccine development through this 47-minute lecture from Yale University's Frontiers of Biomedical Engineering course. Delve into the fundamentals of vaccines and their interaction with the immune system. Examine the historical impact of smallpox and trace the systematic development of its vaccine, starting with Edward Jenner's groundbreaking work. Learn about methods for widespread vaccine distribution and consider the potential resurgence of smallpox as a bioterrorism threat. Gain insights into the intersection of biomedical engineering and immunology, from the basics of vaccine science to its applications in global health and security.