Explore the fascinating field of epigenetics and its impact on human health and disease in this comprehensive lecture by Shelly Berger. Delve into key topics such as RNA modifications, histones, and histone modifications, while gaining insights into the role of P53 in cancer development. Learn about wildtype P53 function, its domain structure, and how it acts as an oncogene. Examine hotspot mutations, P53 cells, and the MLL knockdown mechanism. Discover the intricate connections between epigenetics and human cancer, providing a solid foundation for understanding this crucial area of biological research.