Learn about Systemic Lupus Erythematosus (SLE) in this comprehensive physician grand rounds presentation by Dr. Scott A. Vogelgesang, a rheumatology expert from the University of Iowa. Explore the epidemiology, natural history, and pathophysiology of SLE, using the mnemonic SOAP BRAIN MD to understand its various manifestations. Delve into specific symptoms and complications, including oral/nasal ulcers, cutaneous involvement, photosensitivity, serositis, and effects on pulmonary, cardiac, musculoskeletal, and neuropsychiatric systems. Examine renal and hematologic implications, as well as immunologic aspects. Discover treatment options, including NSAIDs, hydroxychloroquine, corticosteroids, cyclophosphamide, mycophenolate, belimumab, and rituximab, with a focus on therapy for glomerulonephritis. Gain valuable insights into managing SLE and learn about factors to avoid for better patient outcomes.