Explore the evolution and current management of HIV in this comprehensive physician grand rounds lecture. Delve into the history of HIV, its global impact, and modern treatment approaches. Learn about risk factors, diagnostic tests, and the principles of HIV care. Examine case studies, understand the challenges faced by the aging HIV population, and discover the latest developments in prevention and potential cures. Gain valuable insights into HIV management, including antiretroviral therapy, preventive care, and future treatment prospects.